Clinical Trials

5 studies in Aging

1. Control of Secretion of Adrenocorticotropic Hormone (ACTH) in Older Men and Women Rochester, MN View Summary
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   Control of Secretion of Adrenocorticotropic Hormone (ACTH) in Older Men and Women

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   ACTH is a hormone (a chemical that circulates in the blood and influences a person's health) that is made in and released by the pituitary gland in the brain. ACTH increases the production of cortisol by the adrenal gland. Cortisol is a life-supporting hormone, which allows the body to respond to stress. Thus, ACTH and cortisol are called stress hormones. Their levels differ in men and women, but doctors do not know why. This study will test how testosterone (male sex hormone) in men and estrogen (female sex hormone) in women control the stress hormones. This question is important, because sex hormones increase in puberty and decrease with aging.

   IRB Number:

   877-04

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   Who can I contact for additional information about this study?

   Please contact endoresearch@mayo.edu if interested or call 507-255-1294 for more study information.

2. Pulsatile Feedback Actions of Cortisol on ACTH Release in Men and Women: Signaling via Glucocorticoid and Mineralocorticoid Receptor-Dependent Mechanisms Rochester, MN View Summary
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   Pulsatile Feedback Actions of Cortisol on ACTH Release in Men and Women: Signaling via Glucocorticoid and Mineralocorticoid Receptor-Dependent Mechanisms

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   This research study is designed to help us better understand how the body controls the secretion of adrenocorticotropic hormone (ACTH) in young men and women.
   
   ACTH is a hormone (a chemical that circulates in the blood and influences a person's health) that is made in and released by the pituitary gland in the brain. ACTH increases the production of cortisol by the adrenal gland.
   
   Cortisol is a hormone which allows the body to respond to stress. Thus, ACTH and cortisol are called stress hormones.
   
   Their levels differ in men and women, but doctors do not know why. This study will test how testosterone (male sex hormone) in men and estrogen (female sex hormone) in women control the stress hormones.
   
   This question is important, because sex hormones increase in puberty and decrease with aging.
   

   IRB Number:

   09-007226

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   Who can I contact for additional information about this study?

   Please contact Jean Wigham 507-293-1188

3. Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults Rochester, MN View Summary
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   Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   The loss of muscle mass and function with age leads to high social and economic costs. Lifestyle interventions that can help maintain muscle mass and function can be beneficial to improve health and decrease the costs associated with loss of independence in the elderly. Muscle proteins accumulate damage during aging, which is suggested to lead to loss of function. The biological processes that remove damaged proteins and synthesis new proteins appear to be decreased with aging. Exercise is known to increase the processes that remove older and synthesis newer muscle proteins and may be an effect lifestyle intervention to improve muscle quality and function. Additionally, specific types of proteins appear to decay with age including contractile and mitochondrial proteins. Different types of exercise training can increase the making of specific proteins. The investigators will examine the ability for aerobic and resistance training to increase the quality of mitochondrial and contractile proteins between younger and older people.

   NCT ID:

   NCT01477164

   IRB Number:

   10-005853

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   Who can I contact for additional information about this study?

   Rochester: Deborah Sheldon 507-255-8082
                       
   
   
   

4. Novel Methodology to Measure Protein Accumulation Rochester, MN View Summary
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   Novel Methodology to Measure Protein Accumulation

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   Accumulation of damaged proteins is thought to underlie many degenerative conditions, including aging, diabetes, Alzheimer's disease, cataracts, and others. Over time, proteins can be irreversibly damaged by a variety of factors, such as reactive oxygen species, and without timely degradation they can accumulate and aggregate. We believe this can contribute to the development of chronic degenerative disorders. The purpose of this study is to develop a novel methodology for measuring protein accumulation and test it in two groups of people: young (18-30 years) and old (≥65 years). This methodology will require that people drink a solution of essential amino acids that includes isotopically labeled L[ring-13C6]phenylalanine. We will then collect blood and muscle samples, to isolate plasma and skeletal muscle proteins. Participants will return to the study center four more times on a weekly interval. We hypothesize that older proteins, which persisted in circulation and accumulated over time, will have a higher degree of post-translational oxidative damage than newly synthesized proteins.

   NCT ID:

   NCT01505621

   IRB Number:

   11-004969

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   Who can I contact for additional information about this study?

   Rochester: Deborah Sheldon 507-255-8082
                       Rozalina Grubina, MD
   
   
   

5. The Effect of Mixed Exercise and Metabolic Stress in Relationship to Age in Healthy Men Rochester, MN View Summary
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   The Effect of Mixed Exercise and Metabolic Stress in Relationship to Age in Healthy Men

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   Aging in men reduces the amount of luteinizing hormone (LH) and testosterone (Te) secreted in each burst. Stress-associated mechanisms introduced by acute illness and chronic disease decrease LH and Te secretion further. A major unresolved issue is whether the aging process heightens the negative effects of a stressor (whether physical or metabolic) upon LH and Te secretion. This study will assess LH and Te secretion in response to a physical stressor (maximal exercise) and a common metabolic stressor (hyperglycemia) as a function of age in healthy men ages 18-80 yr.

   NCT ID:

   NCT01800370

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   Who can I contact for additional information about this study?

   Rochester: Jean Wigham, BSN 507-293-1188
                       Sue Weist, BSN 507-255-1294