Clinical Trials

7 studies in Smoking

1. Varenicline Treatment for Active Alcoholic Smokers Rochester, MN View Summary
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   Varenicline Treatment for Active Alcoholic Smokers

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   Seventy smokers who are currently alcohol dependent will be enrolled to this study. If found to be study eligible they will be randomized to either active varenicline or placebo for 12 weeks. During these two weeks, they will be seen either weekly or biweekly. At the end of treatment, they will be followed up for an addition 12 weeks. Their last study visit will be 6 months after randomization.

   NCT ID:

   NCT01347112

   IRB Number:

   10-008559

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   Who can I contact for additional information about this study?

   Rochester: Judy A. Trautman, RN 507-266-1944
                       Richard A. Morris, BA 507-266-1944
   
   
   

2. Support Person Effectiveness Study to Promote Smoker Utilization of the QUITPLAN Helpline Rochester, MN View Summary
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   Support Person Effectiveness Study to Promote Smoker Utilization of the QUITPLAN Helpline

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   This study is being done to learn the helpfulness of a telephone-based program for support persons living in MN who are worried about a cigarette smoker living in MN. This study will help support person learn new ways to be supportive as well as encourage a smoker to call the QUITPLAN Helpline. The QUITPLAN Helpline is the tobacco Helpline for the state of Minnesota. Research shows that Helpline?s are an effective way for smokers to quit or make a plan to quit. The person you want to support does not need to be interested in or even thinking about quitting smoking in order for you to be in the study. If the smoker does choose to call QUITPLAN, they are eligible for free services (counseling and/or nicotine replacement therapy) for seven months. The seven months starts on the date of support person enrolling into our study.

   IRB Number:

   11-001796

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   Who can I contact for additional information about this study?

   Christina Smith 800.957.2950 toll-free 507.538.8210 local supportpersonstudy@mayo.edu

3. Acupuncture for Smoking Cessation Rochester, MN View Summary
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   Acupuncture for Smoking Cessation

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   Although most studies indicate no efficacy of acupuncture for smoking cessation, study methodology is weak and problematic. Although most studies indicate no efficacy of acupuncture for smoking cessation, study methodology is weak and problematic.

   IRB Number:

   11-001911

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   Who can I contact for additional information about this study?

   Mayo Clinic Nicotine Research Program 200 First St., SW Rochester, MN 55905 1-800-848-7853 or 507-266-1944 nicotineresearch@mayo.edu

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4. Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders. Rochester, MN View Summary
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   Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   This study is an extension protocol for study A3051123. No treatment is provided during this study. This study is to monitor for cardiovascular events 28 weeks after completion of A3051123. This study is an extension protocol for study A3051123. No treatment is provided during this study. This study is to monitor for cardiovascular events 28 weeks after completion of A3051123.

   NCT ID:

   NCT01574703

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   Who can I contact for additional information about this study?

   - Mayo Clinic Cancer Center - Phone: 507-538-7623 - Research Volunteer Program - Phone: 1-800-664-4542 (toll-free) Email: clinicaltrials@mayo.edu - International Research - Phone: 507-284-8884 Email: intl.mcr@mayo.edu

5. Decision Aid for Cigarette Smokers Undergoing Surgery Rochester, MN View Summary
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   Decision Aid for Cigarette Smokers Undergoing Surgery

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   Smokers have three choices when faced with surgery: keep smoking, quit for a short time around surgery or quit for good. In the first specific aim, a decision aid was designed to help facilitate the discussion of these choices between smokers and healthcare providers. This second aim will test whether this decision aid improves the decisional quality compared with standard methods used to discuss perioperative smoking.

   NCT ID:

   NCT01575119

   IRB Number:

   11-009150

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   Who can I contact for additional information about this study?

   Rochester: Brenda K Anderson, RN 507-255-7157
                       
   
   
   

6. Helping Hospitalized Patients Quit Smoking Rochester, MN View Summary
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   Helping Hospitalized Patients Quit Smoking

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   The study is being done to determine whether an in-hospital intervention using a brief intervention to facilitate quitline utilization will increase quitline utilization by hospitalized smokers, and will increase post hospital discharge smoking abstinence rates. Study participants will be randomized to receive either a brief quitline facilitation intervention , or a control intervention of a brief stop-smoking message. The study will also compare healthcare costs and utilization in the first six months following hospitalization between the two groups.

   NCT ID:

   NCT01575145

   IRB Number:

   12-002207

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   Who can I contact for additional information about this study?

   Rochester: Anita E Baumgartner, RN 507-255-6804
                       
   
   
   

7. Varenicline for Light Smokers Rochester, MN View Summary
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   Varenicline for Light Smokers

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   Nearly 50% of U.S. cigarette smokers smoke ≤ 10 cigarettes per day (CPD) and are considered "light smokers." Most light smokers will either maintain a chronic light smoking habit or increase their level of smoking during their lifetime. Importantly, light smokers are at risk for adverse health consequences and increased all-cause mortality. While multiple factors such as reinforcement behavior, diminished autonomy, economic constraints and tobacco control policies influence light smoking, nicotine dependence appears particularly important in 5 to 10 CPD smokers. Despite the high prevalence of light smoking and its increased healthcare burden, few studies have evaluated the efficacy of pharmacotherapy for this group of smokers. Varenicline, which targets symptoms of nicotine dependence, has been shown to increase smoking abstinence rates in moderate to heavy smokers (≥ 10 cigarettes per day). However, varenicline has not been evaluated in subjects who smoke < 10 CPD. In the current proposal we will investigate the efficacy of varenicline for smoking cessation in 5 to 10 CPD light smokers who wish to quit. This study will be conducted as a double-blind, placebo-controlled, randomized clinical trial at the Mayo Clinic, enrolling 224 eligible participants who smoke 5 to 10 CPD. Participants will receive behavior therapy and either varenicline or placebo for 12 weeks with follow up through 26 weeks. We will determine if varenicline increases smoking abstinence in light smokers at end-of-treatment and 26 weeks as compared to placebo.

   NCT ID:

   NCT01639560

   IRB Number:

   12-005652

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   Who can I contact for additional information about this study?

   Rochester: Ellen J Lichty, BA 507-266-1944
                       Donna F Rasmussen, BSN 507-266-1944