Clinical Trials

2 studies in Heart Attack

1. Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Rochester, MN View Summary
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   Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   Activase, the study drug, is a fibrinolytic drug that is indicated for use in acute myocardial infarction, acute ischemic stroke, and acute massive pulmonary embolism in adults. Previous studies have established the ability of rt-PA to lyse venous thrombus in patients with deep vein thrombosis (DVT), and suggest that successful rt-PA mediated thrombolysis can prevent the post-thrombotic syndrome (PTS), a morbid, late complication of DVT that occurs in nearly 50% of patients. rt-PA is delivered directly into venous thrombus using a catheter/device which is embedded within the thrombus by a physician under imaging guidance. This method of rt-PA delivery, pharmacomechanical catheter-directed intrathrombus thrombolysis (PCDT),is thought to be safer, more effective, and more efficient than previous methods. The question of whether PCDT using rt-PA improves long-term DVT patient outcomes with acceptable risk and cost has not yet been addressed. The rationale for performing the ATTRACT Trial is based upon: - the major burden of PTS on DVT patients and the U.S. healthcare system - the association between rapid clot lysis and prevention of PTS - the proven ability of rt-PA to dissolve venous thrombus in proximal DVT - recent advances in CDT methods which may lower bleeding risk - the major clinical controversy on whether CDT should be routinely used for first-line DVT therapy

   NCT ID:

   NCT00790335

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   Who can I contact for additional information about this study?

   Rochester: Connie L. Sathre 507-538-0540
                       
   
   
   

2. Prediction of Cardiovascular Events in Vulnerable Patients Following Acute Coronary Syndrome Rochester, MN View Summary
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   Prediction of Cardiovascular Events in Vulnerable Patients Following Acute Coronary Syndrome

   Location:

   Rochester, MN

   Trial status:

   Open for Enrollment

   Why is this study being done?

   The purpose of this study is to determine if testing patients for endothelial dysfunction will help identify which patients are more likely at risk to have another heart attack in the future. Study participants will undergo mental stress testing while at the same time being connected to a device that measures endothelial function via the EndoPAT device. These same participants will also undergo a sleep study via the WATCHPAT device.

   NCT ID:

   NCT01500902

   IRB Number:

   09-000047

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   Who can I contact for additional information about this study?

   Rochester: Rebecca E. Nelson, CCRC 507-255-8388