ACTH is a hormone (a chemical that circulates in the blood and influences a person's health) that is made in and released by the pituitary gland in the brain. ACTH increases the production of cortisol by the adrenal gland. Cortisol is a life-supporting hormone, which allows the body to respond to stress. Thus, ACTH and cortisol are called stress hormones. Their levels differ in men and women, but doctors do not know why. This study will test how testosterone (male sex hormone) in men and estrogen (female sex hormone) in women control the stress hormones. This question is important, because sex hormones increase in puberty and decrease with aging.
Sixty-four healthy male or female volunteers, ages 45-75, with diverse ethnic and racial backgrounds, to take part in the study.
Review of Medical History
4 Overnight visits to the Clinical Research Unit
Blood sampling with each overnight visit through an IV
Oral KTCZ @ 2200 & 0600 the following morning
IV administration of Cortisol versus a stimulatory hormone (AVP or CRH)
The total duration of the study will be 2-4 months, depending upon when we can schedule your visits.
Last updated: 01/11/2013