Hypothesis: ECG-gated multidetector CT and ECG-gated Dual Source CT can be used to create multiple volumetric datasets of the abdominal aorta over the time period of the cardiac cycle, allowing for direct and regional calculations of abdominal aortic distensibility over the entire volume of the abdominal aorta, providing insight into risk of abdominal aortic aneurysm rupture and early large vessel stiffness.
- AAA must be at least 3 cm to a maximum 4.9cm cross-sectional diameter.
- BMI 31 or less.
- Creatinine results <2.0 and within six months prior to scan.
- US patients must have only normal creatinine (0.9 to 1.4) for one year before study visit.
- Patients who are originally scheduled for US, who are then subsequently rolled in this study, will have only a ultrasound scan as followup after the initial CTA.
- Creatinine > 2.0.
- Creatinine <0.9 or >1.4 for those who are scheduled for US.
- Atrial fibrillation or other arrythmia.
- Known AAA greater than 5 cm in size.
- Allergy to contrast dye.
Participants selected for this study will undergo a computerized tomography angiography (CTA) of their abdomen and pelvis on the Siemens 64 Multidetector, located at the Clinical Innovation Center in the Mayo Building.
This testing will involve placing an intravenous catheter in the arm to administer an iodine contrast during the scan. Three electrode sticky-pads will be placed on the chest to monitor your hearts rhythm during scanning. Some participants may need to have blood drawn for a creatinine level prior to scanning. Women of child bearing age may need a blood draw for pregnancy testing prior to scanning.
Participants will be followed for two years, or less should they have surgical treatment for their aneurysm. When the participant's physician orders future CTA or abdominal ultrasound tests to measure their aneurysm, those tests will be moved to the Clinical Innovation Center's Multidetector scanner and they will have the CTA repeated. Should the participant's physician order an abdominal ultrasound test, we will utilize those measurements from that test for this research study's purposes.
Last updated: 11/07/2012
NCT ID: NCT00587977