A group of doctors and scientists at the Mayo Clinic in Rochester, Minnesota, along with doctors from many other medical centers throughout the US, are working together to advance our understanding of Barrett's esophagus and esophagus cancer. The main aim of the present study is to collect blood for future testing. Once all the samples have been collected, tests to identify genes that may be involved in the development of Barrett's will be performed. A future goal is to learn if there is a genetic difference between those people who have Barrett's and develop cancer, and those who do not.
As a study participant you will be asked to:
There are no monetary costs to you as part of your participation in the study. Some of your time, however, will be spent completing a questionnaire and having your blood drawn (only once). You may send your bill for blood collection to the Mayo Clinic so that you will not be charged. If you choose not to participate, you will not jeopardize present or future medical care and treatment by your doctor or doctors at the Mayo Clinic.Barrett's esophagus is a complication of gastroesophageal reflux disease (GERD). In Barrett's esophagus, reflux of gastric contents damage the normal lining of the lower esophagus, which is then replaced by a different type of lining (intestinal metaplasia with goblet cells). Patients with Barrett's have a 30-125 times increased risk of developing esophagus cancer compared to the general population. Adenocarcinoma of the esophagus, which usually arises in a Barrett's esophagus, has been increasing in incidence in the United States by 4%-10% per year in recent decades. The cause of the increase is unknown. Similarly, the role of genetic factors in Barrett's esophagus and esophagus cancer is not known.
Last updated: 03/06/2013