Bone marrow and blood samples from both non-sensitized kidney transplant recipients and sensitized kidney transplant recipients will be collected. The samples will be used to compare the effect immunosuppression has on the antibody producing cells from both of these kinds of transplant recipients. Bone marrow will be collected from sensitized kidney transplant recipients before desensitization therapy prior to transplantation and at the time of kidney transplant surgery. Non-sensitized patients will have bone marrow collected only at the time of kidney transplant surgery. Blood will be collected at the same time point that the marrow is collected in both kinds of patients.
Participants must be between the ages of 18 and 70 years of age and undergoing a kidney transplant.
Samples will be taken and compared from two different groups of kidney transplant recipients. The non-sensitized kidney transplant recipients will have blood drawn at the same time blood is collected for routine tests. Bone marrow will also be collected prior to desensitization therapy and also at the time of transplant.
During the first bone marrow collection, participants may choose to have intravenous sedation or local anesthesia. Collection of bone marrow at the time of transplant will take place after genereal anesthesia. Collection of bone marrow at the time of transplant will take place after general anesthesia has been given.
Participants will be involved in this study until blood and bone marrow samples are received, up until the time of transplant.
Last updated: 12/20/2010
NCT ID: NCT00275717
IRB Number:374-05
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