Clinical Trials

Cough Reflex Sensitivity and Bronchial Hyper-responsiveness

Location:

Jacksonville,  FL

Trial status:

Open for Enrollment

Why is this study being done?

The aim of this study is to provide pilot data on the possible gastrointestinal predictors of respiratory hyper-responsiveness and how these relate to the clinical sub-types of GERD and visceral acid hypersensitivity.

Who is eligible to participate?

Inclusion Criteria:

- symptomatic reflux(ie one symptom at least one day a week, with at least 'moderate' severity)

- no evidence of esophagitis

- non-smokers

Exclusion Criteria:

- previous gastrointestinal surgery (excluding minor surgeries, such as cholecystectomy, appendectomy

- active peptic ulcer disease

- Zollinger Ellison Syndrome

- Barrett's esophagus

- eosinophilic esophagitis

- cardiac disease

- diabetes or neurological deficit

- use of tricyclics

- selective serotonin reuptake inhibitors

- narcotics or benzodiazepines

- current use of medications that may affect symptoms of perception,lower esophageal sphincter basal pressure, acid clearance time or acid suppression

- antibiotics within 60 days

- Nursing mothers will be excluded

- allergies to citrus

- asthma

- chronic lung disease

- heart attack or stroke within the last three months

- hypersensitivity to methacholine products

- know aortic aneurysm

- uncontrolled hypertension (defined as systolic pressure greater than 200 or diastolic greater than 100)

- reduced pulmonary function test (forced expiratory volume in one second [FEV1] or the FEV1 to forced vital capacity [FEV1/FVC] ratio of less that 70% of predicted value)

- None of the controls will have any GERD symptoms or ever used antireflux treatment.

Last updated: 01/24/2013

NCT ID:

NCT01777867