Clinical Trials

Protective Ventilation Using High or Low PEEP

Location:

Rochester,  MN

Trial status:

Open for Enrollment

Why is this study being done?

This study will address whether a lung-protective mechanical ventilation strategy protects against post-operative pulmonary and extra-pulmonary complications, and shortens length of hospital stay.

Who is eligible to participate?

Inclusion criteria:

- High or intermediate risk for postoperative pulmonary complications following abdominal surgery, according to the ARISCAT risk score (higher or equal than 26)

Exclusion criteria:

- Age < 18 years

- Body mass index > 40 kg/m2

- Laparoscopic surgery

- Previous lung surgery (any)

- Persistent hemodynamic instability, intractable shock (considered hemodynamic unsuitable for the study by the patient's managing physician)

- History of previous severe chronic obstructive pulmonary disease (COPD) (non- invasive ventilation and/or oxygen therapy at home, repeated systemic corticosteroid therapy for acute exacerbations of COPD)

- Recent immunosuppressive medication (receiving chemotherapy or radiation therapy within last 2 months)

- Severe cardiac disease (New York Heart Association class III or IV, or acute coronary syndrome, or persistent ventricular tachyarrhythmia's)

- Mechanical ventilation > than 30 minutes (e.g., in cases of general anesthesia because of surgery) within last 30 days

- Pregnancy (excluded by laboratory analysis)

- Acute lung injury or acute respiratory distress syndrome expected to require prolonged postoperative mechanical ventilation

- Neuromuscular disease (any)

- Consented for another interventional study or refusal to participate in the study

Last updated: 04/23/2012

NCT ID:

NCT01585116