Clinical Trials

Pilot Study of Varenicline to Treat Opioid Dependence

Location:

Trial status:

Closed

Why is this study being done?

The objective of this proposal is to explore the potential of varenicline as a pharmacotherapeutic agent for opioid dependence and addiction.

Who is eligible to participate?

Inclusion criteria

- Age>=21 years

- Use of opioids at admission to PRC, with daily morphine equivalent dose>=60mg

- Be able and willing to participate fully in all aspects of the study including one month follow-up after completion of PRC

- Ability to provide informed consent

Exclusion criteria

- Currently using varenicline or other pharmacotherapy for nicotine dependence

- Currently pregnant, lactating, or likely to become pregnant during the trial and not willing to use an acceptable form of contraception;

- History of a major cardiovascular event in the past 6 months including unstable angina, acute myocardial infarction, stroke, or coronary angioplasty;

- Known varenicline allergy

- Use of any medication (e.g., methadone, Suboxone) as maintenance therapy for opiate addiction

- Identification of illicit drugs (e.g., marijuana, cocaine) on the baseline urine toxicology screen

Last updated: 01/22/2013

NCT ID:

NCT01436474