Specific aims of the protocol:
1. To quantify the effect of a single administration of 200mg pregabalin on colonic sensory and motor functions in constipation predominant IBS adults.
2. To assess the potential relationship between any analgesic properties of pregabalin and its effect on compliance in constipation predominant IBS adults.
3. To estimate if pregabalin 200mg dose reduces colonic sensation ratings and increases pain thresholds by 50% related to placebo.
Male or females with Constipation Predominant IBS, age 18-65
1. abdominal surgery other than appendectomy, laparoscopic cholecystectomy, cesarean section, vaginal or laparoscopic hysterectomy or tubal ligation,
2. uncontrolled hypertension,
3. use of medications that may interact with the study medication,
4. use of any of the study medications within the past 30 days,
6. history of chronic renal insufficiency (serum creatinine >1.5mg/dL) and
7. psychiatric or psychologic dysfunction
8. current pelvic floor dysfunction
Last updated: 02/25/2013