Clinical Trials

Effects of Cranberry Juice on Risk Factors for Cardiovascular Disease

Location:

Trial status:

Closed

Why is this study being done?

Study participants will be randomized assigned to drink either placebo (a drink that looks and tastes like cranberry juice, but does not contain cranberry juice) or a double strength Ocean Spray light cranberry juice cocktail for four months.

Who is eligible to participate?

Inclusion Criteria:

- Subjects over the age of 18 years old with known or suspected cardiovascular disease including documented CAD by cardiac catheterization, and multiple cardiovascular risk factors will be included, regardless of severity of endothelial dysfunction or previous history of cardiovascular events.

- Subjects with no known history of cardiac disease will also be eligible to participate.

- Subjects must demonstrate endothelial dysfunction via the RH-PAT test (an RH-PAT score of less than 2.0) to continue participating in this study.

Exclusion Criteria:

- Patients will be excluded if they have confounding factors including, but not limited to, history of renal or liver failure, or relevant food allergies (cranberries, etc.).

What is involved?

The purpose of this study is to find out if the use of cranberry juice in your daily diet will improve endothelial function. Endothelial dysfunction is when the tissue lining in the arteries is not functioning correctly. To determine if you have endothelial dysfunction you will have a special test called EndoPAT. This is a non-invasive test that will take about 20 minutes. If you qualify after the EndoPAT test you will have an intravenous line placed in your arm. Your blood will be drawn and you will be asked to complete a questionnaire. You will then drink either 8oz of cranberry juice or placebo. After a 45 minute rest period your blood will be drawn again and another EndoPAT test will be performed. The minimum appointment time is 1 hour and the maximum appointment time is 3.5 hours. You will also need to fast for 4 hours prior to testing.

You will receive either a 4 month supply of cranberry juice or placebo. The daily intake will be 16 oz. After 4 months you will be asked to do another EndoPAT test, blood draw and a questionnaire.

How long is the study?

Four Months

Last updated: 08/10/2011

NCT ID:

NCT00631306