This study is being done for people with upper abdominal discomfort or pain, early fullness after eating, nausea and/or upper abdominal bloating.
We propose to investigate whether antidepressant medications are efficacious in functional dyspepsia. The prescription of antidepressants to treat functional dyspepsia is based on three propositions. First, antidepressants could reduce the severity of co-morbid psychological symptoms, especially anxiety and depression. Second, antidepressants have central analgesic actions. Thirdly, antidepressants have been shown to have local pharmacological actions on the gut, and may specifically alter gastric emptying and fundic relaxation based on preliminary data, but the relevance of such perturbations to treatment outcome is not established.
People who experience stomach discomfort or pain after eating, or other stomach problems.
Nutrient drink test (Ensure) at baseline and week 12 of study medication, gastric emptying test at baseline and week 12 of study medication. Several questionnaires at screening, during treatment phase, and end of follow up phase. Daily symptom diaries during screening and treatment phase, medication diary during treatment phase.
9 months total. 12 weeks on study medication, 6 months follow up phase.
Last updated: 05/18/2012