IRB Number:

2326-05

Trial Status:

Open for Enrollment

Phase: I

Why is this study being done?

This study is being done to collect information from Fuchs' Endothelial Corneal Dystrophy (FECD) patients and their family members so that researchers can explore the genetic likelihood that would cause a person to develop FECD.

The National Eye Institute (NEI) is funding the study.

Who is Eligible to Participate in the Study?

Males and females, age 18 and older, who have been diagnosed with Fuchs' Endothelial Corneal Dystrophy (FECD).

Minimum Age:

18

What is Involved With this Study?

Upon a screening test to determine eligibility, participants will have one of the following procedures performed: Blood draw of about 40 milliliters (3 tablespoons) from a vein in the arm for genetic testing, or collection of a saliva (spit) sample of about 2 milliliters (a little less than half a teaspoon) for genetic testing. Your visit will last approximately 1.5 hours.

Because this is a study to understand the genetics of FECD, family members may have an opportunity to complete an examination that is similar to the examination of your relative who has been diagnosed with FECD.

How long will the Study run?

Participation in the study will involve an eye exam, a blood draw or collection of saliva (spit), and the use of corneal slide specimens following your surgery. If the participant has not already had a corneal transplant but will have one in the next 5 years, the study may last for up to 6 years.

Who can I Contact for Additional Information on this Trial?

For more information or to participate in this study, please contact Margaret J. Ruszczyk at (507) 284-5052.

What is/are the Locations of this Clinical Trial?

• Rochester, MN

Last updated: 11/05/2008