IRB Number:

959-05

Trial Status:

Open for Enrollment

Phase: II

Why is this study being done?

This research study involves the use of a drug called Bevacizumab. Bevacizumab is currently approved by the Food and Drug Administration (FDA) as a treatment for patients with metastatic colon cancer. It is not approved as a treatment for angiosarcoma, so it is considered experimental in this study. Bevacizumab works by blocking a substance in a persons body called endothelial growth factor, or VEGF. VEGF is found in many normal tissues and is important in the making of new blood vessels (both normal and abnormal) in a persons body. Cancerous tumors may cause too much VEGF to be made. This study is being done to find out what effects (good and bad) Bevacizumab has on a patient and angiosarcoma; find out what side effects this drug causes and how often they happen.

Who is Eligible to Participate in the Study?

Adult patients with angiosarcoma having received no prior treatment; or received usual treatment for the disease and not responded; or having the tumor grow back after shrinking in size or going away after treatment with chemotherapy or surgery.

What is Involved With this Study?

• Physical exams


• Blood and urine tests


• CT scan (a type of x-ray scan)


• Possible PET scan (positron emission tomography)


• Medication given through a vein

How long will the Study run?

Patients may continue treatment as long as the tumor is responding to medication.

Sponsor(s): Northwestern University

Study Activation/Registration Date: 09/15/2005

IRB Review and Approval Date: 05/12/2005

Projected Accrual: 5

Costs of Study: There may be standard patient care costs related to participating in a cancer research study.

Principal Investigator: Dr. Scott Okuno

Who can I Contact for Additional Information on this Trial?

Complete Request Form for Cancer Clinical Trial Information at Mayo Clinic or
For more information about this study or other clinical trial options, please contact our Mayo Clinic Cancer Center Clinical Trials Referral Office.

• Patients living within the United States, call 507-538-7623, or e-mail cancerclinicaltrials@mayo.edu


• Patients living outside the United States may call our International Office at 507-284-8884, or e-mail intl.mcr@mayo.edu.

What is/are the Locations of this Clinical Trial?

• Rochester, MN

Last updated: 05/23/2008