IRB Number:

489-04

Trial Status:

Open for Enrollment

Phase: I

Why is this study being done?

The major purpose of this research study is to understand how genetic and environmental exposures contribute to the development of blood or lymph node cancer. This study will improve our understanding of what causes blood or lymph node cancers.

In addition, we hope this study will lead to ways to detect such cancers early, and perhaps, even to prevent them. Patients are asked to participate because either they or a family member is known or thought to have blood or lymph node cancer. There is some evidence that a personal or family history or environmental exposures may increase a person's chances of having a blood or lymph node cancer.

Who is Eligible to Participate in the Study?

The following criteria will be used to considered eligible patients:

• Patients must have LPD and be 18 years or older.


• In addition, patients must have either a family history of LPD or congenital factors (e.g., birth defects, metabolic phenotype, chromosomal anomalies or Mendelian traits associated with tumors).

Identified patients will be invited into the study either through the clinic or mailed an invitation letter and brochure.

Minimum Age:

18

What is Involved With this Study?

If a patient agrees to participate in this study, we would ask the following:

• Answer questions about their health and family history of cancer. Answering these questions may take about 45-60 minutes of time to complete. A questionnaire that contains the questions will be mailed to patient. The patient may answer the questions by filling out this questionnaire and returning it in the enclosed envelope, or they may answer the questions, at their convenience, on the telephone.


• Donate a sample of the patient's blood and cheek cells. A small amount of blood, not greater than 50 ml (about 2 ounces or 4 tablespoons), will be drawn from the patient's vein in the forearm. Cheek cells will be obtained by having the patient swish about one tablespoon of mouthwash inside of their mouth and then discharging it into a collection container. Part of the blood or cheek cells obtained from the patient may be used in studies to determine if there is a genetic contribution to the increased risk of the types of cancers or related conditions present in members of their family. In addition, if the patient has had medical care for blood or lymph node cancer or related illnesses, we may also ask for their written consent to obtain medical records and pathology material related to that care.

How long will the Study run?

Patients will be in this study until blood and cheek cell samples have been collected and the questionnaire information has been obtained, a patient request to withdraw from the study, or it is felt by the investigator to be in the patient's best interest to discontinue, or the study has ended.

Who can I Contact for Additional Information on this Trial?

Complete Request Form for Cancer Clinical Trial Information at Mayo Clinic or

• Mayo Clinic (800) 610-7093


• M.D. Anderson Cancer Center (713) 745-1079


• National Cancer Institute (NCI) at (800) 518-8474


• University of Minnesota (866) 256-4125


• University of California at San Diego (UCSD) at (877) 326-4255


• Duke University (919) 286-0411 Ext. 5248


• University of Utah (801) 587-9305

What is/are the Locations of this Clinical Trial?

• Rochester, MN
• Scottsdale and Phoenix, AZ

Last updated: 03/31/2008